|
KMID : 0359720090270040375
|
|
Journal of the Korean Neurological Association
2009 Volume.27 No. 4 p.375 ~ p.383
|
|
|
Depression and Anxiety in the Epileptic Patients: the Association With Demographic and Seizure-Related Variables
|
|
Heo Seon-Hee
Park Hyeon-Mi
|
|
|
Abstract
|
|
|
Background: Depression and anxiety are common psychiatric symptoms in patients with epilepsy, exerting a profound negative effect on health-related quality of life. Several issues, however, pertaining to their association with psychosocial, seizure-related and medication factors, remain controversial. In the present study we have investigated the association of depression and anxiety with various demographic and seizure-related variables in patients with newly-diagnosed and chronic epilepsy.
Methods: We investigated 80 patients with epilepsy (46.3% males, mean age 36.1±11.4 years, range 18~64; mean disease duration, 13.4±12.2 years). Depression and anxiety were assessed in the interictal state with the Beck Depression Inventory, 21-item version (BDI-21) and the state and trait subscales of the State-Trait Anxiety Inventory (STAI-S and STAI-T), respectively. The association of depression and anxiety with various variables was investigated using univariate analyses and multiple linear regression analyses.
Results: Duration of epilepsy, the number of side effects and the number of GABAergic anti-epileptic drugs were correlated with depression, together accounting for 25.1% of the variation of the BDI-21. The STAI-S index was significantly associated with occupation status and the number of GABAergic anti-epileptic drugs accounting for 27.4% of the variation of the STAI-S. Finally, the number of side effects was correlated with trait anxiety.
Conclusions: Our study shows that the duration of epilepsy, occupation status, GABAergic anti-epileptic drugs and the number of side effects are risk factors for the development of depression and/or anxiety.
|
|
|
KEYWORD
|
|
|
Epilepsy, Depression, Anxiety
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|